History to the pathophysiology of osteoarthritis

    Mr. F is a 38-year-old man in overall good health who has been complaining about an aching pain in his knees when working around the house and often when simply walking. He has noticed that his knees feel “hard” and tight. His history indicates that he has always been involved in athletics and was on the college football team, but recently family responsibilities and work have not made it easy for him to exercise. Relate Mr. F’s case history to the pathophysiology of osteoarthritis. How do anti-inflammatory drugs and analgesics help Mr. F deal with this form of arthritis? Why is moderate, non–weight-bearing exercise recommended? What is the probable prognosis for Mr. F?