Drug therapy for Alzheimer’s disease- donepezil hydrochloride, memantine hydrochloride, and benztropine mesylate
In patients with AD, levels of acetylcholine neurotransmitter are 90% below normal. AD drugs currently in use may slow loss of memory and cognition, and prolong independent function. Cholinesterase inhibitors increase the availability of acetylcholine at cholinergic synapses, that enhance transmission by cholinergic neurons that have not yet been destroyed by AD. They do not cure AD and they do not stop disease progression. They can improve memory and thinking
For each of your groups and assigned drugs, use the NURSE acronym and provide the following as succinctly as possible.
N: Drug class including generic/trade name and MOA
U: Uses-What are some of the therapeutic uses for the drug(s)?
R: How should the drug(s) be given?
What interventions should the nurse use when caring for a patient on this drug(s)?
What are some contraindications that would make taking the drug(s) risky for a patient?
What factors increase the risk of side and adverse effects and thus warrant precautions for a patient on the drug(s)
What drugs or foods have the potential to interact with the drug(s)?
S: What are some of the side and adverse effects of the drug(s)?
E: What important instructions should the nurse give a patient who is taking the drug(s)?