Report About pathogen and disease caused by a pathogen( polio) . Format: 1. general introduction, 2. introduction to the pathogen, 3. mechanism of pathogen infection and its life cycle, 4. Immune response at the site of mucosal entry, immediate mucosal immune response and systemic immune system, 5. History of therapy to infection other than vaccine, 6. Vaccine, 7. Safety of the vaccine and secondary effect of the vaccine, 8. The emergence of an epidemic or pandemic 9. Conclusion and present challenges, 10. Conclusion 11. Bibliograph