“Physical access to DNA is a highly dynamic property of chromatin that plays an essential role in
establishing and maintaining cellular identity”
You should prepare a case study of no more than 1500 words that explores how repressor complexes are
understood to regulate accessibility and activity of chromatin to maintain cellular identity. You should also
discuss the polycomb complex and chromatin access as a potential druggable target and describe how
tools such as CRISPRa and CRISPRi are likely to impact future therapeutic strategies.