Neurobiological of bipolar associated depression

  1- Describe the neurobiological of bipolar associated depression. Include genetics, neurotransmitters, neuroanatomical changes, current theories of the cause of the disease, and cultural factors if it's involved.) 2- what is the neurochemistry action of lamotrigine, side effects to monitor, expected benefits for the patient, and contraindications. 3- Describe the non pharmacological treatment for bipolar. (appropriated therapies)