Patient safety in a hospice facility

  For my proposed PICOT question, I have chosen patient safety. (P) In a hospice facility, (I) how does lowering nurse to patient ration to 1:4, (C) compared to having nurse to patient ratio 1:5, (O) help improve pain management and comfort measures, (T) in a 6-month period. This question is one I wonder how it will impact providing end of life care. How do the sampling methods and sample sizes vary for the different types of quantitative and qualitative research? Hypothetically, what sampling method would you use to conduct a study of your selected evidence-based practice problem/topic? Why? How would you determine the sample type and size?