Introduction to Biochemistry
Lesson 2
During tonight’s class, we discussed protein structure and how changes in the amino
acid sequence of a protein can significantly alter its function and cause
diseases/disorders. With this in mind, write a paragraph that explains the cause of
sickle cell anemia disease?
Your answer should be no longer than one page and should answer ALL of the following
questions:
1. What is the name (spell it out) of the specific protein that is affected in sickle cell
anemia disease?
2. Describe the specific change in the amino acid sequence that causes sickle cell
anemia disease?
3. How does this protein function in normal people who do not suffer from sickle cell
anemia disease?