The evolutionary history of blood components (emphasis on RBC)

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Focus mostly on the evolution of the red blood cell who has evolved to expel the nucleus upon maturation in the mammalian lineage. prior to blood animal complexity was limited due to cellular need for oxygen and lack of means to circulate it. The hemoglobin protein molecule! RBCs are covered with varying surface glycoproteins which are the reason for the different blood types. Diseases like malaria & cholera have made a deep impact on the geographic distribution of blood types.

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