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Target Organ Toxicity

you should write about chemicals that induces toxicity to specific organ. there are five organ which are ( skin- Kidney- blood- heart and Gastrointestinal tract). you have to consider these points:
1- which this organ susceptibility to toxicity
2- mechanisms of toxicity of chemicals
3- target structures
4- how we can assessment of toxicity
1000 max word for each organ, so total 5000 words

I have already chosen the chemicals for each organs:
skin- sulphonamides by mechanism called Phototoxicity
Kidney- Mercury induces proximal tubular necrosis(Tubular toxicity)
blood- Thrombocytopenia Heparin-induced thrombocytopenia
heart- CNS drugs ?( Tricyclic Antidepressants): significant cardiotoxicity, particularly in overdose and includes ECG abnormalities and sudden cardiac death.
Gastrointestinal tract- Non-steroidal In?ammatory Drugs – NSAID users have a 2- to 5-fold greater risk of developing ulcer complications (bleeding, perforation & death) compared to non-NSAID users.

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